A Fully Autologous Cell-based System for Delivery of Molecular Therapeutics to Brain Malignancies

Host Organisation: E.P.O.S IASIS Research And Development Ltd
Partner Organisation(s): PA 1: University of Cyprus
Project Budget: 258.271,20 €
IDEK Funding: 199.924,00 €

BRAIN-THROUGH introduces a new therapeutic solution that focuses on the potential use of iNSCs as vehicles to deliver multitargeted anticancer payloads selectively to tumor sites. These Induced Neural stem cells (iNSC) will be autologous, thus generated with reprogramming of somatic cells derived from the same (or genetically identical) animal, are engineered to produce and release miRNA (i.e. therapy with small, non-encoding nucleotide sequences) that can target and downregulate multiple genes which are responsible for tumour generation and progression.